Do ‘Natural GLP-1 Supplements’ Work As Well As Ozempic?

GLP-1 receptor agonists like Ozempic and Wegovy have proven to be effective in weight loss, backed by significant scientific data. However, these medications can be expensive and sometimes hard to access due to shortages, prompting interest in so-called “natural GLP-1 supplements.” These products claim to mimic the effects of GLP-1 medications but in a more accessible and affordable form.

For example, Kourtney Kardashian’s Lemme GLP-1 Daily and brands like Supergut and Pendulum offer supplements that claim to stimulate the body’s GLP-1 production naturally, using ingredients like prebiotics, saffron extract, and green tea leaf extract. They are often marketed toward women, suggesting they may help balance hormones and reduce appetite.

However, according to obesity medicine experts, the effectiveness of these supplements in replicating GLP-1 receptor agonists like Ozempic remains questionable. Doctors note that these supplements are unlikely to deliver the same results as prescription GLP-1 medications.

GLP-1 medications work by increasing insulin production and slowing food movement through the stomach, which helps control blood sugar and reduce appetite. Natural supplements may impact the body in small ways, but they are not as reliable or potent as pharmaceutical GLP-1s.

Can Natural GLP-1 Supplements Help With Weight Loss?

While there’s some evidence that natural ingredients like berberine and saffron may have mild effects, doctors agree that these supplements don’t compare to the powerful results seen with medications like Ozempic. Increasing protein intake is one natural way to boost GLP-1 production, and focusing on protein-rich meals may offer modest weight-loss benefits. However, for substantial and sustained weight loss, prescription GLP-1 medications remain more effective.

Are Natural GLP-1 Supplements Safe?

For healthy individuals, these supplements are generally considered safe, though it’s always important to check for potential interactions with other medications or stimulants like caffeine. The supplement industry is largely unregulated, so it’s crucial to choose products that are third-party tested and doctor-recommended.

While natural GLP-1 supplements may offer mild benefits, they’re unlikely to match the effectiveness of compounded GLP-1 receptor agonists like Semaglutide or Tirzepatide.